Problem-solving test: Tryptophan operon mutants
نویسندگان
چکیده
منابع مشابه
Regulatory mutants of the tryptophan operon of Salmonella typhimurium.
HE tryptophan ( t rp) operon of Salmonella typhimurium consists of five Tstructural genes regulated as a unit by tryptophan (BLUME and BALBINDER 1966; BAUERLE and MARGOLIN 1966a, 196613; BLUME, WEBER and BALBINDER 1968). The biosynthetic reactions involved and the order of the genes (see Figure 1 ), as well as the regulation of the trp operon have been shown to be identical in Escherichia coli ...
متن کاملPolar and antipolar mutants in the tryptophan operon of Salmonella typhimurium.
Polar mutations in trpA, the first structural gene of the tryptophan operon of Salmonella typhimurium, have an uncoordinate effect on the expression of the distal genes, with trpB, the second gene, being more drastically affected than the last three. A number of these polar mutant strains grow very poorly on anthranilic acid-supplemented minimal medium. By selecting for more rapid growth in the...
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15 صفحه اولTRYPTOPHANYL TRANSF'ER RNA SYNTHETASE AND EXPRESSION OF THE TRYPTOPHAN OPERON IN THE trp8 MUTANTS OF ESCHERICHIA COLI
I N addition to their role in protein synthesis, aminoacyl tRNA synthetases in bacteria have been shown to have a regulatory role in the formation of enzymes involved in the synthesis of corresponding amino acids. This has been demonstrated at least in the case of isoleucine and valine (EIDLIC and NEIDHARDT 1965; YANIV, JACOB and GROS 1965) and histidine (SCHLESINGER and MAGASANIK 1964; ROTH, A...
متن کاملPolarity and enzyme functions in mutants of the first three genes of the tryptophan operon of Escherichia coli.
N operons which are believed to be transcribed into polycistronic messenger I RNA molecules, some revertible mutations result in a lowered rate of synthesis of enzymes specified by genes operator-distal to the mutated gene. This phenomenon, termed polarity (FRANKLIN and LURIA 1961 ; JACOB and MONOD 1961 ) , has been studied in several organisms and a variety of explanations have been proposed f...
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ژورنال
عنوان ژورنال: Biochemistry and Molecular Biology Education
سال: 2010
ISSN: 1470-8175
DOI: 10.1002/bmb.20439